Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Astrocyte Reactivity / A1-A2 Polarization: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| GFAP | participates_in | gene | 0.68 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| GFAP-Positive Reactive Astrocyte Subtype Delineation | 0.518 | Alzheimer's Disease | SEA-AD Gene Expression Profiling — Allen |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-02 | 5 hypotheses Top: 0.519
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associate [PMID:41905188] | Cetindag AC, Schipke CG, Esselmann H, Kr | The journal of prevention of A | 2026 | 0 |
| Biomarkers for Alzheimer's disease across diverse biological domains: an umbrell [PMID:40680830] | Kang J, Son Y, Yim Y, Cho H, Kim J et al | J Adv Res | 2026 | 0 |
| Potential diagnostic markers in Alzheimer's disease: current perspectives and fu [PMID:40911035] | Zheng M, Wang S, Jia J | Neurodegener Dis Manag | 2026 | 0 |
| Granulocyte and astrocyte markers distinguish MOG-antibody disease and neuromyel [PMID:40988129] | Furlan R, Schaedelin S, Frederiksen JL, | Brain | 2026 | 0 |
| MAO-B status in alcohol use disorder: a [(11)C]SL25.1188 PET imaging study of pu [PMID:41291188] | Best LM, Truong J, McCluskey T, Meyer JH | Mol Psychiatry | 2026 | 0 |
| Association between sleep duration and fluid biomarkers of Alzheimer's disease: [PMID:41610733] | Young VM, Zeynoun J, Ruiz Laza A, Salard | Sleep Med Rev | 2026 | 0 |
| Injectable anti-inflammatory, antioxidant supramolecular nanofiber hydrogel for [PMID:41624514] | Liu A, Sheng K, Li H, Zhao X, Zhang X et | Mater Today Bio | 2026 | 0 |
| NRF2 deficit prevents pathologic Tau seeding and spreading in an induced tauopat [PMID:41650822] | López-Sampere Y, Mengod Soler P, Roca-Pe | Redox Biol | 2026 | 0 |
| Decoding Alzheimer's disease through down syndrome: insights from a genetically [PMID:41709686] | Russell JK, Schlachetzki Z, Rafii MS | Curr Opin Neurol | 2026 | 0 |
| Longitudinal Metabolic Alterations of the Visual Cortex in Diabetic Retinopathy [PMID:41732018] | Shen D, Wang Y, Wang Y, Wang R, Wang M e | NMR Biomed | 2026 | 0 |
| Blood-based biomarkers of Alzheimer's disease: potential utility in clinical pra [PMID:41732138] | Zeng X, Nicholson N, Karikari TK | Curr Opin Neurol | 2026 | 0 |
| Role of astrocyte biomarker GFAP in early diagnosis and prognosis assessment of [PMID:41850459] | Li S, Wei S, Wang L, Yu T, Wang H et al. | Int J Biol Macromol | 2026 | 0 |
| Biocompatible Lubricant-Coated Flexible Neural Probes with Enhanced Long-Term Re [PMID:41860566] | Lee H, Lee S, Hwang KS, Kim G, Hong Y et | ACS Appl Bio Mater | 2026 | 0 |
| Ythdf2/Setd1b regulatory axis is essential for cerebellar development through re [PMID:41933071] | Ren X, Jiang J, Hu X, Zhang M, Li J et a | Mol Psychiatry | 2026 | 0 |
| Amyloid-related imaging abnormalities in Japanese patients with Alzheimer's dise [PMID:41936348] | Shimasaki R, Kurihara M, Bannai T, Hatan | J Prev Alzheimers Dis | 2026 | 0 |
| Impact of zervimesine on the neuroinflammatory biomarker GFAP and related proteo [PMID:41943055] | Di Caro V, Cho E, Thiel J, Lizama BN, Ko | Alzheimer's research & therapy | 2026 | 0 |
| Association of plasma glial fibrillary acidic protein and APOE-ε4 with Alzheimer [PMID:41946261] | Zhu Y, Lan G, Li A, Zhang L, Jiang M et | Neurobiol Aging | 2026 | 0 |
| Assessing treatment response in multiple sclerosis. [PMID:41947653] | Föttinger F, Krajnc N, Bsteh G | Curr Opin Neurol | 2026 | 0 |
| Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protei [PMID:41948987] | Kabak EG, Voermans MMC, Heijst H, Teunis | Ann Clin Transl Neurol | 2026 | 0 |
| Astrocyte-related proteins mediate the association of YWHAG with Alzheimer's pat [PMID:41957344] | Zhang Z, Huang P, Yang Y, Wu H, Yao X et | Transl Psychiatry | 2026 | 0 |